How Leptin, Ghrelin, and other Hormones can Thwart your best efforts to get “thin.”

In 1950, researchers at Maine's Jackson Labs produced a strain of Mice labeled OB/OB, or Obese/Obese, as both parents carried a recessive mutation that was expressed in Obesity. This recessive mutation was found to cause the mice to become three times as large as normal mice, and their appetites were ravenous. They were inactive and …

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